this week i

returned to new kitchen.  pelosi dressed as captain of starship enterprise, i drove to rosemarie, cheesesteaks, barnes foundation.  hieronymus bosch knew how to have fun, as did fifteenth century germans with egg tempera and gold leaf, sixteenth century cheshire cat koreans, pointillists, picasso

failed solomonis it in the pacific? // isn't everything?  wealth destruction: underwater homeowners give the keys back to the bank..jingle mail

read the emperor of all maladies: a biography of cancer by siddhartha mukherjee

uncontrollable pathological cell division

an osteosarcoma, a thousand-year-old cancer preserved inside of a mummy

it was in the time of hippocrates, around 400 bc, that a word for cancer first appeared in the medical literature: karkinos, from the greek word for "crab."  the tumor, with its clutch of swollen blood vessles around it, reminded hippocrates of a crab dug in the sand with its legs spread in a circle

melancholia, the medieval name for "depression," would draw its name from the greek melas, "black," and khole, "bile"

the rays penetrated through her hand and left a silhouette of her finger bones and her metallic wedding ring on the photographic plate - the inner anatomy of a hand seen as if through a magical lens.  "i have seen my death"

sisyphus on chemotherapy

what has santa nixon given us lately

old age inevitably drags cancer with it, like flotsam on a tide

medical journals routinely carried cigarette advertisements

statistics..are human beings with the tears wiped off

the discipline of modern biology in its early days often operated like the man in the proverbial story who is frantically searching for his keys under a streetlamp.  when a passerby asks the man whether he lost his keys at that spot, the man says that he actually lost them at home - but he is looking for the keys under the lamp because "the light there is the brightest"

both cancer prevention and chemotherapy had diminished breast cancer mortality equally - 12 percent for mammography and 12 percent for chemotherapy, adding up to the observed 24 percent reduction in mortality.  "no one," as berry said, paraphrasing the bible, "had labored in vain"


this week i

met ezra with his hands in his pocketses.  i asked huseyin the time, i have an apple watch.  barbican postwar modern housed eleven persons, one donkey.  chefane proclaimed 10 years to make a habit regarding epping forest morning runs.  the chechen warlord wears prada.  both trish and damico appeared seven times.  we squeaked clean, ate at hitchcock's, folded swans, discussed seneca, cheered hyde park soccer, studied the library



this week i

published on english language proficiency among medicaid enrollees after covid

wrote a poem, illustrated as well


learned basic photo editing from amin at pathshalawhen in doubt, use tiff.  every pixel contains its own information.  a color pixel needs at least twenty-four zeroes and ones, difference between 1-bit binary and 8-bit grayscale quite stark.  feather decreases circumference of selection with blurring at the edges.  in a layer mask, black paint and white paint add and subtract lower layers.  points on a path called anchors.  the background layer cannot be transparent - quick, make a copy.  patch tool easily removes someone from a photo.  cng driver impounded me, smoked me home



browsed rahul talukder's dhaka opera, with dr. strangelovechild.  botanic garden penguins reminiscent of god of small things kangaroo-pouch dustbins



read the selfish gene by richard dawkins

 the fundamental unit of selection, and therefore of self-interest, is not the species, nor the group, nor even, strictly, the individual.  it is the gene, the unit of heredity

one oarsman on his own cannot win the oxford and cambridge boat race.  he needs eight colleagues.  each one is a specialist who always sits in a particular place of the boat - bow or stroke or cox etc.  rowing the boat is a cooperative venture, but some men are nevertheless better at it than others.  suppose a coach has to choose his ideal crew from a pool of candidates, some specializing in the bow position, others specializing as cox, and so on.  suppose that he makes his selection as follows.  every day he puts together three new trial crews, by random shuffling of the candidates for each position, and he makes the three crews race against each other.  after some weeks of this, it will start to emerge that the winning boat often tends to contain the same individual men.  these are marked up as good oarsmen.  other individuals seem consistently to be found in slower crews, and these are eventually rejected.  but even an outstandingly good oarsman might sometimes be a member of a slow crew, either because of the inferiority of the other members, or because of bad luck - say a strong adverse wind.  it is only on average that the best men tend to be in the winning boat

treat the individual as a survival machine built by a short-lived confederation of long-lived genes

if all the five strategies i have mentioned are turned loose upon one another in a computer simulation, only one of them, retaliator, emerges as evolutionarily stable.  prober-retaliator is nearly stable.  dove is not stable, because a population of doves would be invaded by hawks and bullies.  hawk is not stable, because a population of hawks would be invaded by doves and bullies.  bully is not stable, because a population of bullies would be invaded by hawks.  in a population of retaliators, no other strategy would invade, since there is no other strategy that does better than retaliator itself

the poker face is evolutionarily stable

the minimum requirement for a suicidal altruistic gene to be successful is that it should save more than two siblings (or children or parents), or more than four half-siblings (or uncles, aunts, nephews, nieces, grandparents, grandchildren), or more than eight first cousins, etc.  such a gene, on average, tends to live on in the bodies of enough individuals saved by the altruist to compensate for the death of the altruist itself

the song-bird species that are parasitized by cuckoos have fought back, not in this case by learning the appearance of their own eggs, but by discriminating instinctively in favor of eggs with species-typical markings..but the cuckoos have retaliated in their turn by making their eggs more and more like those of the host species in colour, size, and markings.  this is an example of a lie, and it often works.  the result of this evolutionary arms race has been a remarkable perfection of mimicry on the part of the cuckoo eggs

if c is my identical twin, then i should care for him twice as much as i care for any of my children, indeed i should value his life no less than my own

wynne-edwards..proposes that when huge flocks of starlings mass at evening, or crowds of midges dance over a gatepost, they are performing a census of their population..individuals restrain their birth-rates in the interests of the group as a whole, and have fewer babies when the population density is high, it is reasonable that they should have some way of measuring the population density.  just so; a thermostat needs a thermometer as an integral part of its mechanism.  for wynne-edwards, epideictic behavior is deliberate massing in crowds to facilitate population estimation.  he is not suggesting conscious population estimation, but an automatic nervous or hormonal mechanism linking the individuals' sensory perception of the density of their population with their reproductive systems

when a woman reached the age where the average chance of each child reaching adulthood was just less than half the chance of each grandchild of the same age reaching adulthood, any gene for investing in grandchildren in preference to children would tend to prosper.  such a gene is carried by only one in four grandchildren, whereas the rival gene is carried by one in two children, but the greater expectation of life of the grandchildren outweighs this, and the 'grandchild altruism' gene prevails in the gene pool.  a woman could not invest fully in her grandchildren if she went on having children of her own.  therefore genes for becoming reproductively infertile in middle age became more numerous, since they were carried in the bodies of grandchildren whose survival was assisted by grandmotherly altruism

in one study of elephant seals, 4 per cent of the males accounted for 88 per cent of all the copulations observed

the dowry of a large, nutritious egg

what shall it profit a male if he shall gain the whole world, and lose his immortal genes?

worker sterility..seems to have evolved no fewer than eleven times independently in the hymenoptera and only once in the whole of the rest of the animal kingdom, namely in the termites

true warfare in which large rival armies fight to the death is known only in man and in social insects

we need a name for the new replicator, a noun that conveys the idea of a unit of cultural transmission, or a unit of imitation.  'mimeme' comes from a suitable greek root, but i want a monosyllable that sounds a bit like 'gene'.  i hope my classicist friends will forgive me if i abbreviate mimeme to meme.  if it is any consolation, it could alternatively be thought of as being related to 'memory', or to the french word meme

many wild animals and plants are engaged in ceaseless games of prisoner's dilemma, played out in evolutionary time

imagine the banner headlines if a marine biologist were to discover a species of dolphin that wove large, intricately meshed fishing nets, twenty dolphin-lengths in diameter!  yet we take a spider web for granted, as a nuisance in the house rather than as one of the wonder of the world

to a good approximation, all species are insects


this week i

completed ek dojon lessons in a double megalopolis.  do buffet and munger drink ccz?  guilherme calibrated based on total other than population.  five hundred russians with net worths greater than one hundred million dollars control forty percent of household wealth.  at dawn of agriculture, females reproduced at a rate 17-fold compared to males, i.e. as one of a rare male's seventeen wives.  jay kept me laughing, surprised i knew biral

i have to go to unimart alone because it will take me a long time  //  oh you're one of those

(reads "my hair grows back every night" on profile)  on your back 

wasabi opens up my nostrils.  it's an unnecessary zing

is that shellfish allergy real or do you just not like the taste?  //  i'll die in your arms


roughly calculate if (a) ten billion humans alive today account for five percent of all humans to have ever lived, (b) human populations freeze at a constant ten billion, (c) those ten billion humans refresh - death with replacement - every hundred years, and most importantly (d) we survive a million years without annihilating ourselves, then two hundred billion have ever lived and one hundred trillion would exist over the next million years, and so, in a sample of five hundred humans pulled from the universe of all humans to ever have existed, on average, you would be the first

read the call of the wild, white fang, batard, moon-face, brown wolf, that spot, to build a fire by jack london.  first two thematic mirrors with californian judges, then gallows push, dynamite retrieved, trail over farm, lazy shadow, pine snow extinguished life one hundred below the frostline

 the unbridled anger of a kidnapped king

mercy was a thing reserved for gentler climes

the bottom's likely to drop out at any moment.  only fools, with the blind luck of fools, could have made it.  i tell you straight, i wouldn't risk my carcass on that ice for all the gold in alaska

the menacing truce that marks the meeting of wild beasts that prey

three hundredweight more than half a ton he weighed; he had lived a long, strong life, full of fight and struggle, and at the end he faced death at the teeth of a creature whose head did not reach beyond his great knuckled knees

feathered with arrows like a porcupine

it's a' that accounts for fatty an' frog.  she's the decoy for the pack.  she draws out the dog an' then all the rest pitches in an' eats 'm up

where's lord alfred

forgotten already were the vanquished rivals and the love-tale red-written on the snow

the stinging lash of the thirty-foot cariboo-gut whip

thus, he was strong from the two days' eating a lynx had afforded him, when the hungry wolf-pack ran full tilt upon him

you can never cure a chicken-killer

i could never have believed that such an ungainly man could run so fast.  but run he did, bellona hot-footed after him, and gaining.  and then, just as she caught up, he in full stride, and she leaping with nose at his knee, there was a sudden flash, a burst of smoke, a terrific detonation, and where man and dog had been the instant before there was naught to be seen but a big whole in the ground

as he turned to go on, he spat speculatively.  there was a sharp, explosive crackle that startled him.  he spat again.  and again, in the air, before it could fall to the snow, the spittle crackled.  he knew that at fifty below spittle crackled on the snow, but this spittle crackled in the air

it struck him as curious that he could run at all on feet so frozen that he could not feel them when they struck the earth and took the weight of his body.  he seemed to himself to skim along above the surface, and to have no connection with the earth.  somewhere he had once seen a winged mercury, and he wondered if mercury felt as he felt when skimming over the earth